GPC3 and in situ carcinoma: For example, all five CIS insertions in region XqA5 are less than 5 kb from the three miRNAs listed but more than 120 kb from the assigned RIS gene Gpc3, and four out of seven CIS insertions in region 11qC are closer to mir-142 than to the nearest assigned gene Supt4h2. It is also possible that that (some) miRNA genes have chromatin structure open to retroviral integration similar to promoter regions of protein coding genes.