Western blot and densitometry analysis (figure 5) showed a decreased expression of IGFBP-4 by tumours of both BP-4 and control M groups and an increased expression by Control P group (0.63 ± 0.03 vs 0.75 ± 0.09 vs1.04 ± 0.06, BP-4 vs control M vs Control P, P = 0.002). Here, IGFBP4 is linked to neoplasm.