IGFBP4 and neoplasm: It showed that IGFBP-4 gene therapy treatment resulted in higher concentration of apoptotic cells in tumours when compared to control group tumours (apoptotic cells/100 total cells) (11.47 ± 1.51 vs 3.59 ± 0.17 vs 4.47 ± 0.55, BP-4 vs Control M vs Control P, P = 0.0002).