IGFBP4 and neoplasm: The Bax protein was over-expressed in tumours after IGFBP-4 gene therapy when compared with control groups (3.37 ± 1.15 vs 4.11 ± 1.30 vs 6.31 ± 1.16; Control P vs Control M vs BP-4; P = 0.23) (figure 6).