GSK3B and plasma cell myeloma: However, it remains to be seen whether the induction of Wnt signalling either by GSK3β inhibition, or by antibody administration may affect the metastatic potential of OS cells since Wnt signalling and/or β-catenin upregulation has been shown to be a key regulator of migration in prostate tumours, multiple myeloma cells and also in OS cells (Iwaya et al, 2003; Qiang et al, 2005; Hall et al, 2006).