RGS5 and Hypertension: Differences were also found in expression of genes involved in mitochondrial activity, lipid metabolism, calcium handling, adenylate cyclase, ion transport and protein kinase C. In contrast, coordinate upregulation in both forms of hypertension was found for caveolin-1 and its interaction and modification by the membrane-associated tyrosine kinase Fyn (Figure 3, blue shape), and coordinate downregulation of Rgs2 and Rgs5, the regulators of G protein signalling (Tables 3, 4).