Interestingly, although all three S100 proteins are expressed in the MDA-MB-468 cancer cell line and in the normal epithelial cell lines in anoikis, IFN-gamma treatment had no effect on the expression levels of calgranulin A and calgranulin B. This may indicate that IFN-gamma interferes with signals that specifically modulate psoriasin expression. This evidence concerns the gene S100A9 and cancer.