Mutations of βigh3 are responsible for 5q31-linked human autosomal dominant corneal dystrophies such as granular corneal dystrophy (GCD), Reis-Bückler corneal dystrophy (RBCD), lattice corneal dystrophy (LCD) type I and IIIA, and Avellino corneal dystrophy (ACD) [8,9]. This evidence concerns the gene TGFBI and granular corneal dystrophy type II.