EGFR and non-small cell lung carcinoma: To study the mechanisms of EGFR TKI-induced cell death, all three research teams took advantage of the large number of NSCLC cell lines that have been characterized in terms of their EGFR mutational status and cytotoxic response to the EGFR TKIs gefitinib and erlotinib: H3255, PC-9, and HCC827 cell lines showed the most dramatic apoptotic responses; H1975, A549, and H460 cells were resistant; and H1650 cells showed an intermediate response.