Costa and colleagues also described a new EGFR mutation (L747S) in a tumor with acquired EGFR kinase inhibitor resistance and showed that IL3-independent Ba/F3 cells overexpressing this allele showed an intermediate degree of BIM1 induction and intermediate levels of apoptosis in response to gefitinib (i.e., relative to the hypersensitive L858R mutant and the resistant L858R/T790M mutant). The gene discussed is EGFR; the disease is neoplasm.