The current studies demonstrate that activation of the intrinsic cell death pathway through induction of BIM is also required to elicit an apoptotic response to EGFR TKIs in NSCLC cells harboring mutant EGFR. While this observation remains to be formally proven in patients, it should be emphasized that the preclinical models used in these studies have a strong track record of predicting drug response and drug resistance in patients with NSCLC and EGFR mutations [13,21–24]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.