We tested this hypothesis in gefitinib-sensitive HCC827 stable cell lines expressing activating deletion mutant L747-S752 (HCC/Del) EGFR or in the gefitinib-resistant lines HCC827-delL747-S752-T790M (HCC/Del-TM), harboring both the delL747-S752 and T790M mutations [25], as well as the H1975 cell line harboring L858R-T790M double mutations [24,25]. Here, EGFR is linked to hepatocellular carcinoma.