Squamous cell carcinomas revealed frequent promoter methylation, that is in >40% of cases, of CDH13 (nine out of 16: 56.3%), DAPK1 (nine out of 16: 56.3%), MGMT (15 out of 16: 93.8%) and CADM1 (nine out of 16: 56.3%). The gene discussed is CADM1; the disease is squamous cell carcinoma.