APC and neoplasm: Several tumour types have also shown aberrant methylation at the CpG island in other genes, including the FAP-associated gene APC (Esteller et al, 2000), detoxifying gene GSTP1 (Lee et al, 1994), DNA repair gene MGMT (Esteller et al, 1999a), the potential metastasis inhibitor gene DAP-kinase (Esteller et al, 1999b), and Rb interact gene RIZ1 (Du et al, 2001).