PGR and neoplasm: The tumour factors were the Nottingham Prognostic Index (NPI) (Elston and Ellis, 1991) calculated from histological grade 1, 2 or 3+Nodal status (no positive nodes=1, 1–3 nodes=2 and >3 nodes positive=3)+0.2 × size of the tumour in cm, oestrogen–progesterone receptor (ER/PR) positivity status and node positivity status.