As in the cancer cell lines, we observed promoter hypomethylation in the primary tumors; the frequency of hypomethylation was 5% (1/20) for ANKRD30A, 20% (4/20) for FLJ40201, 0% (0/20) for INSL6, 30% (6/20) for SOHLH2, 20% (4/20) for FTMT, 25% (5/20) for C12orf12, and 30% (6/20) for DPPA5. This evidence concerns the gene INSL6 and cancer.