TGFB1 and hereditary hemorrhagic telangiectasia: Genetic mutations in members of the TGF-β signal pathway, generally result in tumorigenesis, and have been repeatedly linked to human cancer [46-49] TGF-β dysfunction is also causal for hereditary hemorrhagic telangiectasia [50], corneal dystrophy [51], Camurati-Engelmann Disease of bone [52] glomerulonephritis [53], scar formation [54], keloids [55], pulmonary fibrosis [56], and liver cirrhosis [57].