Interestingly, knock-down of LASP-1 by RNA-interference in metastatic breast cancer cell lines BT-20 and MCF-7, as well as in the ovarian cancer cell line SKOV-3 resulted in a strong inhibition of proliferation, migration and in cell cycle arrest in G2-phase without induction of apoptosis or necrosis. Here, LASP1 is linked to breast cancer.