BRCA1 and neoplasm: The NBR2 gene is located near the BRCA1 gene on Chromosome 17, which is responsible for tumor repressor activity in the human genome, and shares a common promoter for transcription, forming a bidirectional transcriptional unit with BRCA1. Although the complete NBR2 cDNA sequence is ∼1.3 kb, it has a short open reading frame (112 amino acids), and is subject to nonsense-mediated decay [45,46].