MTHFR and hyperinsulinemic hypoglycemia, familial, 4: In the literature, various hereditary thrombophilias such as activated protein C resistance, the factor V leiden mutation (both homozygosity and heterozygosity), the prothrombin G20210A mutation, protein S deficiency, the methylenetetrahydrofolate reductase (MTHFR) C677T mutation, hyperhomocysteinemia, or combinations of the above disorders have also been linked to pregnancy loss at varying stages of gestation [2,3].