RXRs bind to DNA as obligate heterodimers with peroxisome-proliferator activated receptors (PPARs) that regulate the transcription of genes involved in fatty acid metabolism.15 Another possible mechanism explaining the link between RBP4 and NAFLD is that changes in retinoid metabolism induced by RBP4 might alter the tissue level of retinol. The gene discussed is RBP4; the disease is metabolic dysfunction-associated steatotic liver disease.