ALPP and invasive carcinoma: By counting and classifying pancreatic lesions (Table 1), we found that (i) the average tumor incidence in bitransgenic mice infected with RCASBP-dnE-cad (n = 11) was 1.5-fold higher than that in bitransgenic mice injected with the control RCASBP-ALPP viruses (n = 6); (ii) mice injected with RCASBP-dnE-cad (n = 11) exhibited a higher incidence of invasive carcinomas than mice injected with the control viruses (n = 6); and (iii) mice injected with RCASBP-dnE-cad had a higher tumor burden than controls (p = 0.003, n = 6 for each group, Wilcoxon rank sum test).