However, no significant changes in the signaling strength of RHO, CDC42, RAC1, or RAS were detected in the tumor cells infected with RCASBP-Bcl-xL, compared with the uninfected parental cells (data not shown), indicating that altered activities of these four proteins were not responsible for the remodeling of the actin skeleton in the tumor cells infected with RCASBP-Bcl-xL. The gene discussed is RAC1; the disease is neoplasm.