However, this association was not present with SVO which is caused predominantly by a diffuse disease in smaller arterioles (lypohyalinose) and to a lesser extent by atherosclerosis [22], Thus, PCSK9 seems to affect atherosclerosis development similarly in different vascular beds of similar calibre and determine Cerebrovascular LVA as well as CHD events. The gene discussed is PCSK9; the disease is coronary artery disorder.