PCSK9 promotes degradation of the low density lipoprotein receptors (LDLR) in liver through an unknown posttranscriptional mechanism [13] In the large long-term Atherosclerosis Risk in Communities study, some sequence variations of the PCSK9 gene associated both with low LDL cholesterol levels and reduced incidence of coronary events [6]. Here, LDLR is linked to atherosclerosis.