However, it should also be taken into account that even resting TAP-deficient NK cells perform ADCC, and that IL-2-activated NK cells from these patients are cytotoxic towards tumor cell lines and some (EBV-transformed B cells and fibroblasts) but not other (PHA-induced T cell blasts) autologous targets, which suggests that they might have underwent some educational mechanism that partly failed because self-tolerance is not constantly maintained. The gene discussed is IL2; the disease is neoplasm.