NME2 and neoplasm: Since the NDPK-B enzyme can be expressed as both an ecto- or exo-enzyme and help to regenerate 8–12% of ADP in blood back to ATP (Buxton et al, 2001), it may play a significant role in angiogenic regulation especially in the setting of apoptosis and necrosis associated with tumour growth as a source of triphospho-nucleotide donor.