TP53 and familial pancreatic carcinoma: In the past few years, a number of cancer-related genes could be identified in pancreatic cancer, the most common of which are K-ras, DPC4, p53 and p16 (Almoguera et al, 1988; Hahn et al, 1996; Hruban et al, 1998; Slebos et al, 2000).