TP53 and familial pancreatic carcinoma: Hollander et al (1999) could demonstrate that GADD45A is a component of the p53 pathway, contributing to the maintenance of genomic stability. Both p53 and GADD45A are highly expressed in human pancreatic cancer and may be associated with pivotal biological features of pancreatic cancer (Dong et al, 2005). Downregulation of GADD45A, as in our setting, reduces proliferation and induces apoptosis in pancreatic cancer cells (Schneider et al, 2006).