TP53 and neoplasm: Thus, whereas some studies have indicated that p53 gene mutation and/or p53 protein accumulation in tumour cells may be significantly associated with resistance to multimodal therapy and/or poor survival (Seitz et al, 1995; Ribeiro et al, 1998; Sarbia et al, 1998; Krasna et al, 1999; Gibson et al, 2003), others have not found such a correlation (Soontrapornchai et al, 1999; Ito et al, 2001; Shimada et al, 2002; Pühringer-Oppermann et al, 2006).