PFN1 and cancer: In the emerging story on the role of ABPs in cancer, profilin-1 (Pfn1 – a ubiquitously expressed G-actin-binding protein) is found to be expressed at a significantly low level in both human breast cancer tissue and a variety of breast carcinoma cell lines (Janke et al, 2000), pancreatic (Gronborg et al, 2006) and hepatic (Wu et al, 2006) carcinoma cells compared to their normal counterparts.