In the emerging story on the role of ABPs in cancer, profilin-1 (Pfn1 – a ubiquitously expressed G-actin-binding protein) is found to be expressed at a significantly low level in both human breast cancer tissue and a variety of breast carcinoma cell lines (Janke et al, 2000), pancreatic (Gronborg et al, 2006) and hepatic (Wu et al, 2006) carcinoma cells compared to their normal counterparts. The gene discussed is PFN1; the disease is breast cancer.