RAC1 and neoplasm: Since WASP-family proteins, Arp-2/3 as well as their upstream regulators (Rac1, Cdc42) are known to be overexpressed in several invasive cancers including breast cancer (Sahai, 2005), protrusion of tumour cells may be much less sensitive to loss of Pfn1 expression compared to vascular endothelial cells.