It has been shown that the choice of fixative and storage time of tumour tissue, (Atkins et al, 2004) the choice of primary antibody and scoring system (Kersting et al, 2006), and the lack of standardised criteria for evaluation (Langner et al, 2004) all represent potential pitfalls and have a substantial impact on determination of EGFR immunoreactivity. Here, EGFR is linked to neoplasm.