This concept is reinforced by the fact that higher MCM-2 and MCM-5 LIs were observed in the 32 (47.8% of cases) ovarian adenocarcinomas with p53 LI more than 10%, a cutoff that that has been shown to be efficient for the identification of p53 mutations in paraffin blocks staining (Banks et al, 1986). This evidence concerns the gene TP53 and ovarian adenocarcinoma.