The combination of docetaxel and epirubicin without G-CSF support resulted in febrile neutropenia in approximately 15% of cycles in a trial by Pagani et al (1999) and in 4 and 7% of cycles in the trials by Morales et al (2004) and Mavroudis et al (2000), respectively. Here, CSF3 is linked to Decreased total neutrophil count.