Additionally, there have been reports wherein a direct comparison of human and mouse phenotypes allowed for the rapid recognition of disease causal genes (for example, ROR2 as the Robinow syndrome gene [16]; the phenotype of the Abcc6-/- mouse shares calcification of elastic fibers with human Pseudoxanthoma elasticum, PXE, pathology, caused by mutations in human ABCC6 gene [15]). Here, ABCC6 is linked to pseudoxanthoma elasticum (inherited or acquired).