In a regression analysis using fasting adiponectin concentration as the dependent variable, and age, HOMAIR, waist circumference, and fat mass as predictors, waist circumference (β = -3.30; p = 0.002), fat mass (β = -2.68; p = 0.01), and insulin resistance (β = -2.38; p = 0.02) but not age (β = 1.11; p = 0.27) were independent predictors of adiponectin. This evidence concerns the gene ADIPOQ and Insulin resistance.