PLK2 and colon carcinoma: Our results demonstrate that FA exposure in both experimental and environmental settings caused transcriptional activation of C8FW. Considering the anti-apoptotic activity of FA in HT-29 human colon carcinoma cells (Tyihak et al. 2001), increased expression of BHLHB2, PLK2, and C8FW mRNA after FA exposure may play important roles in FA-induced inhibition of apoptosis and carcinogenesis.