Circulating markers of systemic inflammation and endothelial dysfunction, such as soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1) have been shown to predict future CVD (Blankenberg et al. 2001; Hwang et al. 1997; Ridker et al. 1998, 2000). Here, ICAM1 is linked to endothelial dysfunction.