MAP3K5 and Machado-Joseph disease: For example, ASK1 has been implicated in polyglutamine (PolyQ) diseases, which include at least nine inherited neurodegenerative disorders: Huntington's disease (HD), spinobulbar muscular atrophy (SBMA), dentatorubral-pallidoluysian atrophy (DRPLA), six spinocerebellar ataxias, and SCA3/Machado-Joseph disease (MJD).