RPS19 and Blackfan-Diamond anemia: For example, RPS5 haploinsufficiency disrupts cell division and causes developmental and growth phenotypes in Arabidopsis [126]; several CRP genes are haploinsufficient for suppression of nerve sheath tumors in zebrafish [127]; and RPS19 haploinsufficiency is a causative factor of Diamond-Blackfan anemia in humans [128,130].