To our knowledge, only one study has demonstrated increased TRPV1 immunoreactivity in a patient with painful neuropathy (postherpetic neuralgia).22 It is interesting to note that although the authors report a somewhat patchy increase of IENF with increased TRPV1, the immunofluorescence also seems clearly to show increased keratinocyte expression in the skin afflicted with neuropathy. This evidence concerns the gene TRPV1 and postherpetic neuralgia.