TRPV1 and peripheral neuropathy: TRPV1 expression in keratinocytes has recently led researchers to propose that keratinocytes may act as thermal receptors.9 TRPV1 has been shown to be essential for the modalities of pain sensation and thermal hyperalgia.10 However, its role in the pathogenesis of neuropathic pain, such as occurs in peripheral neuropathies, remains controversial.