HSPA5 and neuroblastoma: In the present study, we show that ER stress in a neuroblastoma line expressing mutant SOD1 can provoke SOD1 aggregation in ER and formation of LBHI/Ast-HI-like hyaline inclusion bodies (LHIs), which show SOD1, ubiquitin, GRP78/BiP and ER resident protein (KDEL) immunopositivity similar to the shared cytopathological features of LBHI and Ast-HI.