Furthermore, ultrastructual analysis revealed that the LHIs in neuroblastoma cells were composed of granule-coated fibrils (approximately 15–25 nm in diameter) and granular materials, which are the typical morphological hallmarks of mutant SOD1-linked FALS, and were identical with the Ast-HI found in L84V SOD1 mice (Fig. 5C, F; [38]). The gene discussed is SOD1; the disease is neuroblastoma.