These results reveal that the time interval between engraftment and detectable tumour growth was considerably reduced in mice engrafted with NB8-CXCR4-C3 cells compared to NB8-E6, thus demonstrating that CXCR4 expression in the CXCR4-negative cell line NB8 dramatically accelerated orthotopic tumour growth in vivo (Figure 2a). Here, CXCR4 is linked to neoplasm.