In NB8-CXCR4 cells CXCL12/CXCR4 activates ERK1/2, with oncogenic and tumour-promoting activities, consistent with the report by Hatse et al showing that endogenous CXCL12/CXCR4 signalling axis is critical for neuroblastoma cell survival and proliferation [42]. This evidence concerns the gene MAPK3 and neoplasm.