Instead, we found that hotspots associated with either survival or time to distant metastasis were located on cytobands 8q22.3, 8q24.3, 8q24.11-13 and 11q14, involving other important breast cancer genes such as EDD1, WDSOF1 (8q22.3), THRAP6 (8q24.11), DCC1 (8q24.12), SQLE, KIAA0196 (8q24.13) and NDUFC2, ALG8, USP35 (11q14.1) (Table 2 and Additional Data File 9). This evidence concerns the gene ALG8 and breast carcinoma.