The survival of adCre;Nf2flox2/flox2;Ink4a*/* mice was not reduced compared with that of adCre;Nf2flox2/flox2, but the rate of meningioma development was significantly higher in adCre;Nf2flox2/flox2;Ink4a*/* (10 of 27 histologically examined mice; 37%) compared with adCre;Nf2flox2/flox2 (9 of 72 histologically examined mice; 13%) mice (χ2, P < 0.01). Here, CDKN2A is linked to meningioma.