To correlate the histological findings with the radiological appearance of meningothelial proliferations and meningiomas, we analyzed 27 adCre;Nf2flox2/flox2;Ink4a*/*, 72 adCre;Nf2flox2/flox2 and 9 adLacZ‐injected Nf2flox2/flox2 mice (as negative control) by serial MRI follow‐up (6, 9, 12 and 15 months). This evidence concerns the gene CDKN2A and meningioma.