Significantly higher invasion was promoted by tumor fibroblasts with the MMP-1 1G/1G genotype compared with their normal counterparts (p = 0.025) (Figure 4a.ii) and, similarly, tumor fibroblasts with the MMP-3 5A/5A genotype demonstrated significantly higher IPC than normal fibroblasts with the same genotype (p = 0.04) (Figure 4b.ii). Here, MMP3 is linked to neoplasm.