When genotype status was compared with donor type, no significant difference in SNP status for MMP-1, MMP-3, or MMP-9 was seen in tumor donors versus non-tumor donors (Figure 4), although there was a trend toward higher frequency of the MMP-3 5A/5A genotype amongst the breast cancer donor group, with the OR of relative risk associated with 5A/5A compared to the other two genotypes being 3.21 (95% CI 0.68 to 15.16; p = 0.14). This evidence concerns the gene MMP3 and breast cancer.