Thus, human breast cancer cell lines are heterogeneous in their expression of different VEGF-C-binding receptors, which can potentially mediate autocrine action of VEGF-C including its ability to stimulate cell migration, as documented in other cell types, for example endothelial cells (Makinen et al, 2001), lung cancer cells (Tanno et al, 2004), Kaposi's sarcoma cells (Marchio et al, 1999), and leucocytes (Shang et al, 1999; Young et al, 2001; Chen et al, 2004). Here, VEGFC is linked to sarcoma.