Vascular endothelial growth factor (VEGF)-C is the major lymphangiogenic factor which is expressed in certain normal tissues, for example large intestinal and mammary duct epithelia, skeletal and cardiac muscle, thyroid, ovary, and prostate (Joory et al, 2006) as well as in a variety of cancerous tissues including breast cancer (Kinoshita et al, 2001; Nakamura et al, 2003, 2005, 2006). The gene discussed is VEGFC; the disease is breast cancer.