VEGFA and breast cancer: These findings are highly relevant for human breast cancer progression and metastasis because of two reasons: (a) we have shown that VEGF-C is the dominant product of highly metastatic human breast cancer cells amongst various members of the VEGF family, upregulated by COX-2 – an important marker for breast cancer progression (Timoshenko et al, 2006); (b) VEGF-C expression in human breast cancer is associated with poor prognosis (Nakamura et al, 2003; Mylona et al, 2007).