AQP1 and colorectal cancer: The corresponding values for liver metastasis of colorectal cancer are C4.4A: 0.79 sensitivity (95% CI: 0.63–0.90), 1.00 specificity (95% CI: 90–100%); galectin-3: 0.83 sensitivity (95% CI: 0.70–0.91), 1.00 specificity (95% CI: 0.94–1.00); EpCAM: 0.93 sensitivity (95% CI: 0.83–0.98), 0.91 specificity (95% CI: 0.81–0.97); and CO-029: 0.94 sensitivity (95% CI: 0.85–0.99), 0.94 specificity (95% CI: 0.85–0.99) (Kuhn et al, 2007).