LGALS3 and cancer: However, altered glycosylation in cancer can play an important role in tumour cell adhesion and migration (Orntoft and Vestergaard, 1999), as well as in extravasation via interaction with galectin-3 on endothelial cells (Lehr and Pienta, 1998; Glinsky et al, 2000; Krishnan et al, 2005).