As we observed staining of colorectal cancer tissue with all four antibodies in 79–98%, it implies that irrespective of the possible underestimate particularly of EpCAM and galectin-3 expression in normal tissue, expression of these four molecules is significantly upregulated in colorectal cancer such that expression in primary colorectal cancer and that in liver metastasis differ at a highly significant level from expression in the corresponding normal tissue. The gene discussed is LGALS3; the disease is colorectal cancer.