The possible importance of the protein as tumour marker was indicated by the restricted expression in normal tissues (Rösel et al, 1998; Smith et al, 2001; Würfel et al, 2001) and upregulation of C4.4A mRNA in different tumours (Seiter et al, 2001; Smith et al, 2001; Fletcher et al, 2003). Here, LYPD3 is linked to neoplasm.