It has been reported that the effects of ZD6474 are synergistic with those of oxaliplatin and docetaxel in cells which do not overexpress P-gp, such as KYSE30 esophageal squamous epithelial cancer cells and HCT-116 and HT29 colon cancer cells (Morelli et al, 2005; Troiani et al, 2006). Here, PGP is linked to colonic neoplasm.