The currently ongoing Trial to Reduce Cardiovascular Events with Aranesp (TREAT) [70] is a double-blind study comparing darbepoetin alfa treatment (Hb target, 13 g/dL) versus placebo in patients with type 2 diabetes and CKD to assess effects on cardiovascular morbidity due to acute myocardial ischemia. Here, GSTM1 is linked to type 2 diabetes mellitus.