Because of the observed differential distribution of integrin alphavbeta3 immunofluorescence between the marginal area and the main cell body of the epithelial cells of the breast cancer biopsies compared with those of normal tissues, the relative integrin alphavbeta3 fluorescence intensities per cellular area between normal and cancer cells were measured as described in the "Material and Methods" using image analysis morphometry. The gene discussed is ITGAV; the disease is breast cancer.