The occasional presence of integrin alphavbeta3 immunofluorescence at the rest of the main cell body in the primary breast cancer epithelial cells, as shown by the frequency distribution histogram of the immunofluorescence intensity values, may be, either, due to non-clustered non-activated integrins, where a diffused pattern is observed, or due to de novo-formed clusters of integrin, where immunofluorescent aggregations are displayed. This evidence concerns the gene ITGAV and breast cancer.