In the primary epithelial cells of the breast cancer tissues, the integrin alphavbeta3 immunofluorescence was not observed at the ventral cell surface around the nucleus, suggesting that its recycling was completed via a "short-loop", without passing through the perinuclear recycling compartment, but returning – after its internalization and proceeding to early endosomes – to the plasma membrane [43], in response to the elevated requirements of integrin alphavbeta3 availability due to the higher cellular motility. The gene discussed is ITGAV; the disease is breast carcinoma.