RB1 and neoplasm: To investigate potential growth-suppressive pathways, we took the hT-HDMEC–p53CTer, and also prepared hT-HDMECs stably transduced with retroviruses expressing SV40 large T antigen (hT-HDMEC-LT) or the human papillomavirus oncogenes E6 and E7 (hT-HDMEC-E6/E7) to abrogate the function of both the p53 and pRb tumor-suppressor pathways.