Association results for 408 SNPs in 46 candidate genes (Table 4) revealed suggestive evidence for major CHD events for ALOX5AP (23 SNPs, 7 with p < 0.05 by GEE or FBAT), GJA4 (14 SNPs, 6 with p < 0.05), MEF2A (5 SNPs, 2 with p < 0.05), and PCSK9 (11 SNPs, 3 with p < 0.05). The gene discussed is PCSK9; the disease is coronary artery disorder.