We also evaluated 4 well-replicated genes in the obesity field (ADIPOQ [14], ESR1 [15], LEP [16], and PPARG [17]), as well as the recently identified INSIG2 gene [18]; Table 4a displays the associated validated SNPs from the literature that are either present in the Affymetrix 100K or that are in linkage disequilibrium (LD) with these SNPs. Here, INSIG2 is linked to obesity disorder.