We also evaluated 4 well-replicated genes in the obesity field (ADIPOQ [14], ESR1 [15], LEP [16], and PPARG [17]), as well as the recently identified INSIG2 gene [18]; Table 4a displays the associated validated SNPs from the literature that are either present in the Affymetrix 100K or that are in linkage disequilibrium (LD) with these SNPs. This evidence concerns the gene ESR1 and obesity due to melanocortin 4 receptor deficiency.