These 3 genes, ERBB4, PDLIM5 and RFX4, (FBAT ranks #11 and 12, GEE rank #9) have each been previously associated with schizophrenia or mood disorders, conditions known to be associated with smaller frontal brain volumes and poorer performance on tests of executive function, even in unaffected family members [47,48]. This evidence concerns the gene ERBB4 and mood disorder.