Elevated circulating levels of hemostatic factors, such as fibrinogen [1-3], plasminogen activator inhibitor (PAI-1) [4,5], von Willebrand factor (vWF) [6], tissue plasminogen activator (tPA) [4,5,7], factor VII (FVII) [8], and D-dimer [9,10] are linked to the development of atherothrombosis and are risk markers for coronary heart disease (CHD), stroke and other cardiovascular disease (CVD) events. This evidence concerns the gene PLAT and Stroke.