SETD1A and colorectal cancer: However, recent studies in human cells and colorectal cancer cell lines have shown that the β-catenin carboxy-terminal activation domain associates with TIP60/TRAPPP and a mixed-lineage-leukemia (MLL1/MLL2) SET1-type chromatin-modifying complex in vitro, and that this complex promotes H3K4 trimethylation at the c-Myc target gene in vivo [39-41].